I use Photoshop (CS5) for a good chunk of my stuff, though sometimes I also use Clip/Manga Studio! I highly recommend the latter for Mac users that don’t want to blow tons of money on Photoshop, as it’s a perfectly good program for a far cheaper price. (Photoshop is also great, of course.)

I’ve also been doing lots of traditional media stuff lately - watercolor, generally, but I’ve been messing around with alcohol-based markers as well (Copics and Prismacolors).